TRIP Publications

  1. Wan J, Block S, Scribano CM, Thiry R, Esbona K, Audhya A, Weaver BA. Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Nat Commun. 2019 Apr 4;10(1):1540. doi: 10.1038/s41467-019-09471-9. PMID: 30948704
  2. Faralli JA, Filla MS, Peters DM. Effect of αvβ3 Integrin Expression and Activity on Intraocular Pressure. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1776-1788. doi: 10.1167/iovs.18-26038. PMID:31022732
  3. Kumar M, Salem K, Michel CJ, Jeffery JJ, Yan Y, Fowler AM. 18F-Fluoroestradiol Positron Emission Tomography Imaging of Activating Estrogen Receptor Alpha Mutations in Breast Cancer. J Nucl Med. 2019 Mar 8. pii: jnumed.118.224667. doi: 10.2967/jnumed.118.224667. PMID:  30850489
  4. Spurgeon ME, Uberoi A, McGregor SM, Wei T, Ward-Shaw E, Lambert PF. A Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive Tract. MBio. 2019 Mar 5;10(2). pii: e00180-19. doi: 10.1128/mBio.00180-19. PMID: 30837335
  5. Roy M, Buehler DG, Zhang R, Schwalbe ML, Baus RM,  Salamat MS, Lloyd RV, Rosenbaum JN. Expression of Insulinoma-Associated Protein 1 (INSM1) and Orthopedia Homeobox (OTP) in Tumors with Neuroendocrine Differentiation at Rare Sites. Endocr Pathol. 2019 Mar;30(1):35-42. doi: 10.1007/s12022-018-9559-y. PMID: 30523500
  6. Chu YH, Hardin H, Eickhoff, Lloyd RV. In Situ Hybridization Analysis of Long Non-coding RNAs MALAT1 and HOTAIR in Gastroenteropancreatic Neuroendocrine Neoplasms. Endocr Pathol. 2019 Mar;30(1):56-63. doi: 10.1007/s12022-018-9564-1. PMID: 30600442
  7. Vellky JE, Ricke EA, W Huang, Ricke WA. Expression and Localization of DDX3 in Prostate Cancer Progression and Metastasis. Am J Pathol. 2019 Mar 27. pii: S0002-9440(18)30965-9. doi: 10.1016/j.ajpath.2019.02.011. PMID: 30926334
  8. Roy M, Buehler DG, Zhang R, Schwalbe ML, Baus RM, Salamat, MS, Lloyd RV, Rosenbaum JN. Expression of Insulinoma-Associated Protein 1 (INSM1) and Orthopedia Homeobox (OTP) in Tumors with Neuroendocrine Differentiation at Rare Sites. Endocr Pathol. 2019 Mar;30(1):35-42. doi: 10.1007/s12022-018-9559-y. PMID:30523500
  9. Yang RK, Zhao P, Lu C, Luo J, Hu R. Expression pattern of androgen receptor and AR-V7 in androgen deprivation therapy naïve salivary duct carcinomas. Hum Pathol. 2018 Sep 26. pii: S0046-8177(18)30371-X. doi: 10.1016/j.humpath.2018.09.009. PMID: 30267779
  10. Esbona K, Yi Y, Saha S, Yu M, Van Doorn RR, Conklin MW, Graham DS, Wisinski KB, Ponik SM, Eliceiri KW, Wilke LG, Keely PJ. The Presence of Cyclooxygenase 2, Tumor-Associated Macrophages, and Collagen Alignment as Prognostic Markers for Invasive Breast Carcinoma Patients. Am J Pathol. 2018 Mar;188(3):559-573. doi: 10.1016/j.ajpath.2017.10.025. PMID: 29429545
  11. Salem K, Kumar M, Kloepping KC, Michel CJ, Yan Y, Fowler AM. Determination of binding affinity of molecular imaging agents for steroid hormone receptors in breast cancer. Am J Nucl Med Mol Imaging. 2018 Apr 25;8(2):119-126. eCollection 2018. PMID: 29755845
  12. Roy M, Connor J, Al-Niaimi A, Rose SL, Mahajan A. Aldehyde dehydrogenase 1A1 (ALDH1A1) expression by immunohistochemistry is associated with chemo-refractoriness in patients with high-grade ovarian serous carcinoma. Hum Pathol. 2018 Mar;73:1-6. doi: 10.1016/j.humpath.2017.06.025. Epub 2017 Aug 26. PMID:28851663
  13. Salem , Kumar M, Powers GL, Jeffery JJ, Yan Y, Mahajan AM, Fowler AM. 18F-16a-17b-Fluoroestradiol Binding Specificity in Estrogen Receptor–Positive Breast Cancer1. Radiology: Volume 286: Number 3—March 2018
  14. Salem K, Kumar M, Yan Y, Jeffery J, Kloepping KC, Michel C, Powers GL, Mahajan AM, Fowler AM. Sensitivity and Isoform Specificity of 18FFluorofuranylnorprogesterone for Measuring Progesterone Receptor Protein Response to Estradiol Challenge in Breast Cancer. J Nucl Med. 2018 Jul 20. pii: jnumed.118.211516. doi: 10.2967/jnumed.118.211516. PMID: 30030339
  15. Zhang R, Hardin H, Huang W, Buehler D, Lloyd RV. Long Non-coding RNA Linc-ROR Is Upregulated in Papillary Thyroid Carcinoma. Endocr Pathol. 2018 Mar;29(1):1-8. doi: 10.1007/s12022-017-9507-2. PMID: 29280051
  16. Fleszar AJ, Walker A, Porubsky V, Flanigan W, James D, Campagnola PJ, Weisman PS, Kreeger PK. The Extracellular Matrix of Ovarian Cortical Inclusion Cysts Modulates Invasion of Fallopian Tube Epithelial Cells. APL Bioeng. 2018;2(3). pii: 031902. doi: 10.1063/1.5022595. Epub 2018 Apr 11. PMID:30556046
  17. Denu RA, Shabbir M, Nihal M, Singh CK, Longley BJ, Burkard ME, Ahmad N. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018 Mar;16(3):517-527. doi: 10.1158/1541-7786.MCR-17-0197. Epub 2018 Jan 12. PMID:29330283
  18. Rush PS, Rosenbaum JN, Roy M, Baus RM, Bennett DD, Lloyd RV. Insulinoma-associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma). J Cutan Pathol. 2018 Feb;45(2):129-135. doi: 10.1111/cup.13079. Epub 2017 Dec 17. PMID: 29148079
  19. Chan SR, Salem K, Jeffery J, Powers GL, Yan Y, Shoghi KI, Mahajan AM, Fowler AM. Sex as a Biologic Variable in Preclinical Imaging Research: Initial Observations with 18F-FLT. J Nucl Med. 2018 May;59(5):833-838. doi: 10.2967/jnumed.117.199406. Epub 2017 Dec 7. PMID:29217733
  20. Connor JP, Esbona K, Matkowskyj KA. AKR1B10 expression by immunohistochemistry in surgical resections and fine needle aspiration cytology material in patients with cystic pancreatic lesions; potential for improved nonoperative diagnosis. Hum Pathol. 2017 Dec; 70:77-83. doi: 10.1016/j.humpath.2017.10.006. Epub 2017 Oct 24. PMID: 29079172
  21. Mandal, R., Hardin, H., Baus, R., Rehrauer, W., & Lloyd, R. V. (2017). Analysis of miR-96 and miR-133a Expression in Gastrointestinal Neuroendocrine Neoplasms. Endocrine Pathology, 28(4), 345-350. doi:10.1007/s12022-017-9504-5
  22. Shen AL, Moran SM, Glover EA, Teixeira LB, Bradfield CA (2017) Retinal pathology in the PPCD1 mouse. PLoS ONE 12(10): e0185094
  23. Somnay YR, Yu XM, Lloyd RV, Leverson G, Aburjania Z, Jang S, Jaskula-Sztul R, Chen H. Notch3 expression correlates with thyroid cancer differentiation, induces apoptosis, and predicts disease prognosis. Cancer. 2017 Mar 1;123(5):769-782. doi: 10.1002/cncr.30403. Epub 2016 Nov 2. PMID:27861750
  24. Blute ML Jr, Damaschke N, Wagner J, Yang B, Gleave M, Fazli L, Shi F, Abel EJ, Downs TM, Huang W, Jarrard DF. Persistence of senescent prostate cancer cells following prolonged neoadjuvant androgen deprivation therapy. PLoS One. 2017 Feb 24;12(2): e0172048. doi: 10.1371/journal.pone.0172048. eCollection 2017. PMID:28234906
  25. Swick AD, Stein AP, McCulloch TM, Hartig GK, Ong IM, Sampene E, Prabakaran PJ, Liu CZ, Kimple RJ. Defining the boundaries and expanding the utility of head and neck cancer patient derived xenografts. Oral Oncol. 2017 Jan; 64:65-72. doi: 10.1016/j.oraloncology.2016.11.017. Epub 2016 Dec 8. PMID:28024726
  26. Jang S, Yu XM, Montemayor-Garcia C, Ahmed K, Weinlander E, Lloyd RV, Dammalapati A, Marshall D, Prudent JR, Chen H. Dysadherin specific drug conjugates for the treatment of thyroid cancers with aggressive phenotypes. Oncotarget. 2017 Jan 30. doi: 10.18632/oncotarget.14904. PMID:28160550
  27. Matson DR, Hardin H, Buehler D, Llloyd, R. AKT activity is elevated in aggressive thyroid neoplasms where it promotes proliferation and invasion. Exp Mol Pathol. 2017 Dec;103(3):288-293. doi: 10.1016/j.yexmp.2017.11.009. PMID: 29169802.
  28. Covach A, Patel S, Hardin H, Lloyd RV. Phosphorylated Mechanistic Target of Rapamycin (p-mTOR) and Noncoding RNA Expression in Follicular and Hürthle Cell Thyroid Neoplasm. Endocr Pathol. 2017 Sep;28(3):207-212. doi: 10.1007/s12022-017-9490-7. PMID: 28660408
  29. Damodaran S, Damaschke N, Gawdzik J, Yang B, Shi C, Allen GO, Huang W, Denu J, Jarrard D. Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes. BMC Cancer. 2017 Dec 20;17(1):874. doi: 10.1186/s12885-017-3853-9. PMID: 29262808
  30. Chu YH, Hardin H, Schneider DF, Chen H, Lloyd RV. MicroRNA-21 and long non-coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinoma. Exp Mol Pathol. 2017 Oct;103(2):229-236. doi: 10.1016/j.yexmp.2017.10.002. Epub 2017 Oct 26. PMID: 29107050
  31. Damaschke NA, Yang B, Bhusari S, Avilla M, Zhong W, Blute ML Jr, Huang W, Jarrard DF. Loss of Igf2 Gene Imprinting in Murine Prostate Promotes Widespread Neoplastic Growth. Cancer Res. 2017 Oct 1;77(19):5236-5247. doi: 10.1158/0008-5472.CAN-16-3089. Epub 2017 Aug 3. PMID: 28775169
  32. Lee, JK, Yang B, Lindahl AJ, Damaschke N, Boersma MD, Huang W, Corey E, Jarrard DF, Denu JM. Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development. ACS Chem Biol. 2017 Nov 17;12(11):2804-2814. doi: 10.1021/acschembio.6b01035. Epub 2017 Oct 11. PMID: 28949514
  33. Hardin H, Zhang R, Helein H, Buehler D, Guo Z, Lloyd RV. The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors. Lab Invest. 2017 Oct;97(10):1142-1151. doi: 10.1038/labinvest.2017.41. Epub 2017 Apr 10. PMID: 28394318
  34. Bauman TM, Huang W, Lee, MH, Abel EJ. Neovascularity as a prognostic marker in renal cell carcinoma. Hum Pathol. 2016 Nov;57:98-105. doi: 10.1016/j.humpath.2016.07.005. Epub 2016 Jul 17. PMID: 27436827
  35. Esbona K, Inman D, Saha S, Jeffery J, Schedin P, Wilke L, Keely P. COX-2 modulates mammary tumor progression in response to collagen density. Breast Cancer Res. 2016 Mar 22;18(1):35. doi: 10.1186/s13058-016-0695-3.
  36. Gertz, R. J., Nikiforov, Y., Rehrauer, W., Mcdaniel, L., & Lloyd, R. V. (2016). Mutation in BRAF and Other Members of the MAPK Pathway in Papillary Thyroid Carcinoma in the Pediatric Population. Archives of Pathology & Laboratory Medicine, 140(2), 134-139. doi:10.5858/arpa.2014-0612-oa
  37. C. Baiu, B. Barger, M. Sandor, Z. Fabry, M.N. Hart. Autoantibodies to vascular smooth muscle are pathogenic for vasculitis. Am J Pathol, 166 (2005), pp. 1851-1860.
  38. Xu J, Hardin H, Zhang R, Sundling K, Buehler D, Lloyd RV. Stage-Specific Embryonic Antigen-1 (SSEA-1) Expression in Thyroid Tissues. Endocr Pathol. 2016 Dec;27(4):271-275. PMID:27550342
  39. Drifka CR, Loeffler AG, Mathewson K, Keikhosravi A, Eickhoff JC, Liu Y, Weber SM, Kao WJ, Eliceiri KW Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection. Oncotarget. 2016 Nov 15;7(46):76197-76213. doi:10.18632/oncotarget.12772. PMID:27776346
  40. Drifka CR, Loeffler AG, Mathewson K, Mehta G, Keikhosravi A, Liu Y, Lemancik S, Ricke WA, Weber SM, Kao WJ, Eliceiri KW. Comparison of Picrosirius Red Staining With Second Harmonic Generation Imaging for the Quantification of Clinically Relevant Collagen Fiber Features in Histopathology Samples. J Histochem Cytochem. 2016 Sep;64(9):519-29. doi: 10.1369/0022155416659249. Epub 2016 Jul 22. PMID:27449741
  41. Bauman TM, Vezina CM, Ricke EA, Halberg RB, Huang W, Peterson R, Ricke WA. Expression and colocalization of β-catenin and lymphoid enhancing factor-1 in prostate cancer progression. Hum Pathol. 2016 May; 51:124-33. doi: 10.1016/j.humpath.2015.12.024. Epub 2016 Jan 19.
  42. Bauman TM, Ricke EA, Drew SA, Huang W, Ricke WA. Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging. J Vis Exp. 2016 Apr 8;(110). doi: 10.3791/53837.
  43. George J, Nihal M, Singh CK, Zhong W, Liu X, Ahmad N. Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma. J Invest Dermatol. 2016Apr;136(4):809-18. doi: 10.1016/j.jid.2015.12.026. Epub 2015 Dec 29.
  44. Denu, R. A., Zasadil, L. M., Kanugh, C., Laffin, J., Weaver, B. A., Burkard, M. E. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer201616:47 DOI: 10.1186/s12885-016-2083-x (2016).
  45. Yu W, Denu RA, Krautkramer KA, Grindle KM, Yang DT, Asimakopoulos F, Hematti P, Denu JM. Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. J Biol Chem. 2016 Feb 12;291(7):3268-79. doi: 10.1074/jbc.M115.702076. Epub 2015 Dec 2. PMID:26631723
  46. Choudhary A, Zachek B, Lera RF, Zasadil LM, Lasek A, Denu RA, Kim H, Kanugh C, Laffin JJ, Harter JM, Wisinski KB, Saha S, Weaver BA, Burkard ME. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016;15(1):48-59. Epub 2015/11/21. doi: 10.1158/1535-7163.mct-15-0527. PubMed PMID: 26586723; PMCID: PMC4707107.
  47. Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 2016; 16:47. Epub 2016/02/03. doi: 10.1186/s12885-016-2083-x. PubMed PMID: 26832928; PMCID: PMC4734858.
  48. Francis DM, Huang S, Armstrong EA, Werner LR, Hullett C, Li C, Morris ZS, Swick AD, Kragh M, Lantto J, Kimple RJ, Harari PM. Pan-HER Inhibitor Augments Radiation Response in Human Lung and Head and Neck Cancer Models. Clin Cancer Res. 2016;22(3):633-43. Epub 2015/10/01. doi: 10.1158/1078-0432.ccr-15-1664. PubMed PMID: 26420857.
  49. Gee JR, Saltzstein DR, Messing E, Kim K, Kolesar J, Huang W, Havighurst TC, Harris L, Wollmer BW, Jarrard D, House M, Parnes H, Bailey HH. Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy. Eur J Cancer Prev. 2016;25(4):312-20. Epub 2015/08/28. doi: 10.1097/cej.0000000000000189. PubMed PMID: 26313229.
  50. Iida M, Bahrar H, Brand TM, Pearson HE, Coan JP, Orbuch RA, Flanigan BG, Swick AD, Prabakaran PJ, Lantto J, Horak ID, Kragh M, Salgia R, Kimple RJ, Wheeler DL. Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab. Mol Cancer Ther. 2016;15(9):2175-86. Epub 2016/07/17. doi: 10.1158/1535-7163.mct-16-0012. PubMed PMID: 27422810; PMCID: PMC5010956.
  51. Katsumura KR, Ong IM, DeVilbiss AW, Sanalkumar R, Bresnick EH. GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells. Cell Rep. 2016;16(9):2428-41. Epub 2016/08/23. doi: 10.1016/j.celrep.2016.07.058. PubMed PMID: 27545880; PMCID: PMC5154384.
  52. Wisinski KB, Tevaarwerk AJ, Burkard ME, Rampurwala M, Eickhoff J, Bell MC, Kolesar JM, Flynn C, Liu G. Phase I Study of an AKT Inhibitor (MK-2206) Combined with Lapatinib in Adult Solid Tumors Followed by Dose Expansion in Advanced HER2+ Breast Cancer. Clin Cancer Res. 2016;22(11):2659-67. Epub 2016/03/31. doi: 10.1158/1078-0432.ccr-15-2365. PubMed PMID: 27026198; PMCID: PMC4891227.
  53. Zumwalde NA, Haag JD, Sharma D, Mirrielees JA, Wilke LG, Gould MN, Gumperz JE. Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vdelta2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate. Cancer Prev Res (Phila). 2016;9(4):305-16. Epub 2016/01/27. doi: 10.1158/1940-6207.capr-15-0370-t. PubMed PMID: 26811335; PMCID: PMC4818696.
  54. Kuo PY, Leshchenko VV, Fazzari MJ, Perumal D, Gellen T, He T, Iqbal J, Baumgartner-Wennerholm S, Nygren L, Zhang F, Zhang W, Suh KS, Goy A, Yang DT, Chan WC, Kahl BS, Verma AK, Gascoyne RD, Kimby E, Sander B, Ye BH, Melnick AM, Parekh S. High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma. Oncogene. 2015 Mar 5;34(10):1231-40. PMCID: PMC4511176
  55. Drifka CR, Tod J, Loeffler AG, Liu Y, Thomas GJ, Eliceiri KW, Kao WJ. Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis. Mod Pathol. 2015 Nov;28(11):1470-80. doi: 10.1038/modpathol.2015.97. Epub 2015 Sep 4.
  56. Bauman TM, Becka AJ, Sehgal PD, Huang W, Ricke WA. SIGIRR/TIR8, an important regulator of TLR4 and IL-1R-mediated NF-κB activation, predicts biochemical recurrence after prostatectomy in low-grade prostate carcinomas. Hum Pathol. 2015 Nov;46(11):1744-51. doi: 10.1016/j.humpath.2015.07.015. Epub 2015 Jul 29.
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  58. Bauman TM, Ewald JA, Huang W, Ricke WA. CD147 expression predicts biochemical recurrence after prostatectomy independent of histologic and pathologic features. BMC Cancer. 2015 Jul 25; 15:549. doi: 10.1186/s12885-015-1559-4.
  59. Fakhraldeen SA, Clark RJ, Roopra A, Chin EN, Huang W, Castorino J, Wisinski KB, Kim T, Spiegelman VS, Alexander CM. Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells. J Biol Chem. 2015 May 22;290(21):13386-400. doi: 10.1074/jbc.M115.655175. Epub 2015 Apr 10.
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