Rebecca Baus

Credentials: B.A.

Position title: Molecular, Cell Line Authentication, Spatial and Molecular Profiling, IHC-IF, ISH/FISH

Biography

Becky brings 24 years of experience to TRIP lab where she specializes in Spatial and Molecular profiling using multiple platforms, DNA/RNA extraction from archived or fresh tissue, Cell Line Authentication by STR Analysis, and custom assays based on client’s needs. In addition to her molecular work, she carries out projects involving IHC-IF and ISH/FISH single and multi-plex staining.

Publications

Williams, A.E., Hoffmann, E.J., Inman, D.R. et al. Obesity and breast density enhance immune exclusion in the primary tumor microenvironment and promote breast cancer metastasis. Oncogene (2026). https://doi.org/10.1038/s41388-026-03718-8

Saldanha, Gabriela, Baus, Rebecca. Why Cell Line Authentication Matters More Than Ever. Promega Blog. 2025

Limkar AR., Ricke EA., Vrba SM., Fabry Z., Lee MT., McVary KT., Ricke WA. Targeting fibrosis in the treatment of lower urinary tract dysfunction. Journal of Pathology. 2025.

Chhabra G, Su S, Shirley CA, Thornton J, Rizvi HA, Robarge RK, Krien JM, Ndiaye MA, Ahmad N. A Melanoma-Specific Gene Network Analysis Identifies MZB1 as a Potential Tumor Promoter. J Invest Dermatol. 2025 Jul 30:S0022-202X(25)02310-3. doi: 10.1016/j.jid.2025.07.009. Epub ahead of print. PMID: 40749972; PMCID: PMC12373258.

Crossman BE, Harmon RL, Iida M, Adams JM, Lin CY, Glitchev CE, Juang TD, Kerr SC, Alexandridis RA, Hyun M, Yang DT, Kang I, Salgia R, Wheeler DL. Tumor-associated MerTK promotes a pro-inflammatory microenvironment and enhances immune checkpoint inhibitor response in triple-negative breast cancer. Front Oncol. 2025 May 5;15:1579214. doi: 10.3389/fonc.2025.1579214. PMID: 40391157; PMCID: PMC12086072.

Kim D, Lee JW, Rawding PA, Iida M, Kim C, Kostecki KL, Poellmann MJ, Crossman B, Liu AS, Kim Y, Wheeler DL, Hong S. Dendrimer Conjugates with PD-L1-Binding Peptides Enhance In Vivo Antitumor Immune Response. Adv Healthc Mater. 2025 Aug;14(20):e2500551. doi: 10.1002/adhm.202500551. Epub 2025 Apr 17. PMID: 40244214; PMCID: PMC12333478.

Golfinos-Owens AE, Lozar T, Khatri P, Hu R, Harari PM, Lambert PF, Fitzpatrick MB, Dinh HQ. Integrated single-cell and spatial analysis identifies context-dependent myeloid-T cell interactions in head and neck cancer immune checkpoint blockade response. bioRxiv [Preprint]. 2025 Mar 28:2025.03.24.644582. doi: 10.1101/2025.03.24.644582. PMID: 40196610; PMCID: PMC11974738.

Kostecki KL, Harmon RL, Iida M, Harris MA, Crossman BE, Bruce JY, Salgia R, Wheeler DL. Axl Regulation of NK Cell Activity Creates an Immunosuppressive Tumor Immune Microenvironment in Head and Neck Cancer. Cancers (Basel). 2025 Mar 15;17(6):994. doi: 10.3390/cancers17060994. PMID: 40149328; PMCID: PMC11940164

Zhang X, Lan R, Liu Y, Pillarisetty VG, Li D, Zhao CL, Sarkar SA, Liu W, Hanna I, Gupta M, Hajdu C, Melamed J, Shusterman M, Widmer J, Allendorf J, Liu YZ. Complement activation in tumor microenvironment after neoadjuvant therapy and its impact on pancreatic cancer outcomes. NPJ Precis Oncol. 2025 Mar 3;9(1):58. doi: 10.1038/s41698-025-00848-2. PMID: 40032924; PMCID: PMC11876354.

Mohanty C, Singh CK, Daccache JA, Damsky W, Kendziorski C, Yan D, Prasad A, Zhang D, Keenan T, Drolet B, Ahmad N, Shields BE. Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics. J Invest Dermatol. 2025 Jan;145(1):109-121. doi: 10.1016/j.jid.2024.04.024. Epub 2024 Jun 4. PMID: 38844128.

Minne RL, Luo NY, Mork CM, Wopat MR, Esbona K, Javeri S, Nickel KP, Hernandez R, LeBeau AM, Kimple RJ, Baschnagel AM. Evaluation of a Novel MET-Targeting Camelid-Derived Antibody in Head and Neck Cancer. Mol Pharm. 2024 Dec 2;21(12):6376-6384. doi: 10.1021/acs.molpharmaceut.4c00938. Epub 2024 Nov 8. PMID: 39513517.

Tannenbaum AP, Lozar T, Lu C, Schumacher M, Golfinos A, Dinh HQ, Taylor N, Kimple RJ, Yang D, Harari PM, Lambert PF, Lloyd RV, Hu R. Uncommon and Challenging Phenotypes of High-Risk Human Papillomavirus-Associated Head and Neck Carcinomas Revealed by High-Throughput Studies. Head Neck Pathol. 2024 Oct 22;18(1):112. doi: 10.1007/s12105-024-01707-5. PMID: 39436498; PMCID: PMC11496466.

Crossman BE, Harmon RL, Kostecki KL, McDaniel NK, Iida M, Corday LW, Glitchev CE, Crow MT, Harris MA, Lin CY, Adams JM, Longhurst CA, Nickel KP, Ong IM, Alexandridis RA, Yu M, Yang DT, Hu R, Morris ZS, Hartig GK, Glazer TA, Ramisetty S, Kulkarni P, Salgia R, Kimple RJ, Bruce JY, Harari PM, Wheeler DL. From Bench to Bedside: A Team’s Approach to Multidisciplinary Strategies to Combat Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma. J Clin Med. 2024 Oct 10;13(20):6036. doi: 10.3390/jcm13206036. PMID: 39457986; PMCID: PMC11508784.

Jagodinsky JC, Vera JM, Jin WJ, Shea AG, Clark PA, Sriramaneni RN, Havighurst TC, Chakravarthy I, Allawi RH, Kim K, Harari PM, Sondel PM, Newton MA, Crittenden MR, Gough MJ, Miller JR, Ong IM, Morris ZS. Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade. Sci Transl Med. 2024 Sep 18;16(765):eadk0642. doi: 10.1126/scitranslmed.adk0642. Epub 2024 Sep 18. PMID: 39292804; PMCID: PMC11522033.

Manuel RS, Rundquist A, Ambrogi M, Scharpf BR, Peterson NT, Sandhu JK, Chandrashekar S, Ridlon M, Crawford LK, Keil-Stietz KP, Peterson RE, Vezina CM. The aryl hydrocarbon receptor agonist ITE reduces inflammation and urinary dysfunction in a mouse model of autoimmune prostatitis. Am J Clin Exp Urol. 2024 Aug 25;12(4):149-161. doi: 10.62347/PEGK4888. PMID: 39308590; PMCID: PMC11411176.

Albertini,M.R.; Zuleger,C.L.; Ranheim, E.A.; Shiyanbola, O.; Sondel, P.M.; Morris, Z.S.; Eickhoff, J.; Newton, M.; Ong, I.M.; Schwartz, R.W.; Hayim, R.; Kurzman, I.D.; Michelle, T.; Vail, D.M. Administration of intratumoral GD2-directed interleukin-2immunocytokine and local radiation therapy to activate rejection of spontaneous canine melanoma. Melanoma Research 2024 Aug 1;34(4):307-318. PMID: 38768442. https://journals.lww.com/melanomaresearch/abstract/2024/08000/administration_of_intratumoral_gd2_directed.3.aspx

Iida M, Crossman BE, Kostecki KL, Glitchev CE, Kranjac CA, Crow MT, Adams JM, Liu P, Ong I, Yang DT, Kang I, Salgia R, Wheeler DL. MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer. Int J Mol Sci. 2024 May 8;25(10):5109. doi: 10.3390/ijms25105109. PMID: 38791148; PMCID: PMC11121248.

Heaton AR, Burkard NJ, Sondel PM, Skala MC. Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation imaging. Biophotonics Discov. 2024 May;1(1):015004. doi: 10.1117/1.bios.1.1.015004. Epub 2024 May 20. PMID: 39011049; PMCID: PMC11247620

[abstract]. Paz, Cristina, Annemarie Glassey, Abigail Frick, Lauryn Melzer, Jasmine M. Robinson, Rebecca M. Baus, Randall J. Kimple. Abstract 7446: Transcriptomic and histological analysis of radiation-induced damage in the murine submandibular gland. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl): Abstract nr 7446.

Faralli JA, Filla MS, Yang YF, Sun YY, Johns K, Keller KE, Peters DM. Digital spatial profiling of segmental outflow regions in trabecular meshwork reveals a role for ADAM15. PLoS One. 2024 Feb 23;19(2):e0298802. doi: 10.1371/journal.pone.0298802. PMID: 38394161; PMCID: PMC10889904.

Lechner SA, Welsch JM, Pahapill NK, Kaldenberg TAR, Regenbaum A, Kelm-Nelson CA. Predictors of prodromal Parkinson’s disease in young adult Pink1-/- rats. Front Behav Neurosci. 2022 Sep 12;16:867958. doi: 10.3389/fnbeh.2022.867958. PMID: 36172466; PMCID: PMC9510667.

Ni Z, Prasad A, Chen S, Halberg RB, Arkin LM, Drolet BA, Newton MA, Kendziorski C. SpotClean adjusts for spot swapping in spatial transcriptomics data. Nat Commun. 2022 May 27;13(1):2971. doi: 10.1038/s41467-022-30587-y. PMID: 35624112; PMCID: PMC9142522.

Chhabra G, Singh CK, Guzmán-Pérez G, Ndiaye MA, Iczkowski KA, Ahmad N. Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in Braf^V600E/Pten^NULL Mice. J Invest Dermatol. 2022 Apr;142(4):1145-1157.e7. doi: 10.1016/j.jid.2021.08.434. Epub 2021 Sep 29. PMID: 34597611; PMCID: PMC9199498.

Su S, Ndiaye MA, Guzmán-Pérez G, Baus RM, Huang W, Patankar MS, Ahmad N.Cancers (Basel). Potential tumor suppressor role of Polo-Like Kinase 5 in cancer.2023 Nov 17;15(22):5457. doi: 10.3390/cancers15225457.PMID: 38001717

Patil AT, Bennett DD, Xu J, Weisman P, Matson DR. Spatial transcriptomics of a giant pilomatricoma. J Cutan Pathol. 2023 Nov;50(11):963-970. doi: 10.1111/cup.14524. Epub 2023 Aug 30. PMID: 37649312; PMCID: PMC10591970.

Lozar, T,; Laklouk, I.; Golfinos, A.E.; Gavrielatou, N., Xu, J.; et al. Stress Keratin 17 Is a Predictive Biomarker Inversely Associated with Response to Immune Check-Point Blockade in Head and Neck Squamous Cell Carcinomas and Beyond. Cancers. 2023, Oct, 9. https://doi.org/10.3390/cancers15194905

Heaton AR, Rehani PR, Hoefges A, Lopez AF, Erbe AK, Sondel PM, Skala MC. Single cell metabolic imaging of tumor and immune cells in vivo in melanoma bearing mice. Front Oncol. 2023 Mar 20;13:1110503. doi: 10.3389/fonc.2023.1110503. PMID: 37020875; PMCID: PMC10067577.

Magee K, Marsh IR, Turek MM, Grudzinski J, Aluicio-Sarduy E, Engle JW, Kurzman ID, Zuleger CL, Oseid EA, Jaskowiak C, Albertini MR, Esbona K, Bednarz B, Sondel PM, Weichert JP, Morris ZS, Hernandez R, Vail DM. Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative (companion dog) setting. PLoS One. 2021 Aug 12;16(8):e0255798. doi: 10.1371/journal.pone.0255798. PMID: 34383787; PMCID: PMC8360580.

Narayanan D, Mandal R, Hardin H, Chanana V, Schwalbe M, Rosenbaum J, Buehler D, Lloyd RV. Long Non-coding RNAs in Pulmonary Neuroendocrine Neoplasms. Endocr Pathol. 2020 Sep;31(3):254-263. doi: 10.1007/s12022-020-09626-1. PMID: 32388776.

Roy M, Buehler DG, Zhang R, Schwalbe ML, Baus RM, Salamat MS, Lloyd RV, Rosenbaum JN. Expression of Insulinoma-Associated Protein 1 (INSM1) and Orthopedia Homeobox (OTP) in Tumors with Neuroendocrine Differentiation at Rare Sites. Endocr Pathol. 2019 Mar;30(1):35-42. doi: 10.1007/s12022-018-9559-y.PMID: 30523500

Rush, P. S., Rosenbaum, J. N., Roy, M., Baus, R. M., Bennett, D. D., & Lloyd, R. V. (2017). Insulinoma-associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma). Journal of Cutaneous Pathology. doi:10.1111/cup.13079 https://www.ncbi.nlm.nih.gov/pubmed/29148079

Mandal, R., Hardin, H., Baus, R., Rehrauer, W., & Lloyd, R. V. (2017). Analysis of miR-96 and miR-133a Expression in Gastrointestinal Neuroendocrine Neoplasms. Endocrine Pathology, 28(4), 345-350. doi:10.1007/s12022-017-9504-5 https://www.ncbi.nlm.nih.gov/pubmed/29032398

Gertz, R. J., Nikiforov, Y., Rehrauer, W., Mcdaniel, L., & Lloyd, R. V. (2016). Mutation in BRAF and Other Members of the MAPK Pathway in Papillary Thyroid Carcinoma in the Pediatric Population. Archives of Pathology & Laboratory Medicine, 140(2), 134-139. doi:10.5858/arpa.2014-0612-oa https://www.ncbi.nlm.nih.gov/pubmed/26910217

Rosenbaum JN, Guo Z, Baus RM, Werner H, Rehrauer WM, Lloyd RV. INSM1: A Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial Neoplasms. Am J Clin Pathol. 2015 Oct;144(4):579-91. doi: 10.1309/AJCPGZWXXBSNL4VD.PMID: 26386079.

Bilger, A., Poli, E., Schneider, A., Baus, R., & Drinkwater, N. (2012). The Hcs7 Mouse Liver Cancer Modifier Maps to a 3.3 Mb Region Carrying the Strong Candidate Ifi202b. InTech. doi: 10.5772/32529.

Czarny MJ, Babcock K, Baus RM, Manoharan H, Pitot HC. Hepatocellular carcinomas of the albumin SV40 T-antigen transgenic rat display fetal-like re-expression of lgf2 and deregulation of H19. Mol Carcinog. 2007 Sep;46(9):747-57. doi: 10.1002/mc.20286.PMID: 17393425